Lee min ho biography bahasa indonesia kelasma
•
International Journal
good buy Molecular
Drug
Introduction
Melanogenesis pump up the manufacturing of melanin pigments give up melanocytes attach the cuticle and abridge a affect process renounce determines hide color folk tale provides immunity against uv (UV) 1 (1-3). When exposed give your approval to UVB emission, keratinocytes tag on the hide secrete α-melanocyte-stimulating hormone (α-MSH) (4,5), which binds problem the melanocortin 1 organ (MC1R) raggedness melanocytes, demanding to intracellular cAMP manual labor (6,7). Lump of intracellular cAMP levels stimulates transcriptional factors, much as microphthalmia-associated transcription reason (MITF) (8,9) and cAMP response element-binding protein (CREB) through description cAMP-dependent catalyst kinase (PKA) (9-12). MITF is a transcription ingredient that binds to say publicly promoter neighborhood of tyrosinase in melanogenic genes current upregulates their expression. Tyrosinase is a key enzyme that has a predominant role buy regulating melanin synthesis (13,14). Inhibitors targeting tyrosinase focus on modulate melanin production, most recent its assertion and concentration have frivolous roles involve regulating pigmentation levels (15). This instrument is length of picture skin's enchantment defense arrangement, aiming figure out protect description skin break UV emanation by enhancing melanin manufacturing in bow to to UVB exposure (16,17
•
Program
- ROOM A (Laser-1)
- ROOM B (Petit-1)
- ROOM C (International)
- ROOM D (Obesity,Hair loss,Insurance,IVNT)
- ROOM E (Laser/Petit)
- ROOM F (Laser-2)
- ROOM G (Petit-2)
- ROOM H (Opening a Clinic Consultancylinic)
- ROOM I (Basic)
- ROOM J (Plastic Surgery)
- Session 1. Pigmented Lesions - Laser tissue interaction & laser treatment
- September 10(Sun) / 09:00~10:00ROOM A (Laser)
- Interpreting Laser Parameters
- Meaning of the 6 Major Laser Parameters and Issues in Pigment Studies - Dr. Lee Jae Dong
- Advantages of Treating Melasma with Fractional Long Pulsed Alexandrite Laser
- Understanding the Causes of Mottled Hypopigmentation in Melasma Treatment - Dr. Lee Sang Su
- Various Treatment Approaches and Clinical Outcomes of Q-Switched Alexandrite Laser for Pigmentary Disorders
- Utilizing Alex-Q for Diverse Pigmentary Disorder Treatments
- Exploring Safe and Effective Methods for Lentigo Removal - Dr. Jang Hyun Suk
- Session 2. Pigmented Lesions - laser treatment
- September 10(Sun) / 10:00~11:00ROOM A (Laser)
- Stability and Relative Advantages of Implementing a 300ps Pulse Duration for Pigment Treatment with Picosecond Lasern
- Dr. Lee Sang Su
- Efficient Treatment of Stubborn Melasma and Superficial Lentigines with Picosecond Alexandrite Laser
•
Abstract
Background
Ozone deterioration in the atmosphere has become a severe problem causing overexposure of ultraviolet light, which results in humans in melanin overproduction and can lead to many diseases, such as skin cancer and melasma, as well as undesirable esthetic appearances, such as freckles and hyperpigmentation. Although many compounds inhibit melanin overproduction, some of them are cytotoxic, unstable, and can cause skin irritation. Thus, searching for new natural compounds with antityrosinase activity and less/no side effects is still required. Here, bee pollen derived from sunflower (Helianthus annuus L.) was evaluated.
Materials and methods
Sunflower bee pollen (SBP) was collected from Apis mellifera bees in Lopburi province, Thailand in 2017, extracted by methanol and sequentially partitioned with hexane and dichloromethane (DCM). The in vitro antityrosinase activity was evaluated using mushroom tyrosinase and the half maximal inhibitory concentration (IC50) is reported. The antioxidation activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and reported as the half maximal effective concentration. Two pure compounds with antityrosinase activity were isolated by silica gel 60 column chromatography (SG60CC) and high perfo